The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

PRONE domain, subdomain 2

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: PRONE domain, subdomain 2

Rop (Rho of plants), are small plant specific GTP-binding proteins, which acts as switches in signalling processes. Activation, as with other GTP binding proteins, depends on guanine nucleotide exchange factors (GEFs) which catalyse GDP dissociation for subsequent GTP binding. According to the available literature, structural domains which comprise this superfamily correspond to the structure of a component of PRONE, which stands for Plant-specific Rop nucleotide exchanger and is a highly conserved catalytic domain of RopGEFs. PRONE has been shown to be both necessary and sufficient to promote nucleotide release from Rop PMID:19335195 PMID:15980860.

This domain is however divided in two subdomains, named respectively subdomain 1 and subdomain 2 PMID:17218277 the structure of members of this superfamily corresponds to that of subdomain 2. The function of each subdomain has yet to be determined.

GO Diversity

Unique GO annotations
13 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
118 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 6
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Unique EC:
Unique GO: 13
Unique Species: 118