The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

KEN domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: KEN domain

Structural domains comprising this superfamily share the structure of the KEN domain found in Mammalian 2-5A-dependent RNase or RNase L, an interferon-induced enzyme implicated in molecular mechanisms of interferon action and control of RNA stability, and the eukaryotic Ire1/Ern1, an ancient transmembrane sensor of ER-stress which shows dual protein kinase and ribonuclease activities. Both enzymes share a common architecture with a protein kinase homology domain followed by an approximately 135-residue long globular kinase-extension nuclease (KEN) domain made of eight helices. Their KEN domain is responsible for the ribonuclease activity characteristic of both enzymes PMID:18191223.

GO Diversity

Unique GO annotations
97 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1335 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 77
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 3
Unique PDBs: 23
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 18
Unique EC: 1
Unique GO: 97
Unique Species: 1335