The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
VKOR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: VKOR domain

Structural domains comprising this superfamily share the structure of the VKOR (Vitamin K epoxide reductase) domain, found naturally in complex with its naturally fused redox partner, a thioredoxin-like domain. VKOR generates vitamin K hydroquinone, which is required to sustain gamma-carboxylation of many blood coagulation factors. The catalytic core of VKOR is a four transmembrane helix bundle that surrounds a quinone, connected through an additional transmembrane segment with the periplasmic thioredoxin-like domain PMID:24477003,PMID:20110994.

GO Diversity

Unique GO annotations
25 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
4264 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 14
Function
Unique EC: 1
Unique GO: 25
Taxonomy
Unique Species: 4264