The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Malonyl-CoA decarboxylase, oligemerization domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Malonyl-CoA decarboxylase, oligemerization domain

Structural domains comprising this superfamily share the structure of the N-terminal helical oligemrization domain of Malonyl-CoA decarboxylase (MCD), enzyme which catalyzes the conversion of malonyl-CoA to acetyl-CoA and CO2 and is localized in peroxisomes, and more abundantly in the cytoplasm. MCD is found from bacteria to humans and it has important roles in regulating fatty acid metabolism and food intake. This N-terminal helical domain is involved in the oligomerization of MCDs, although there are important differences in the organization of the dimers and tetramers among MCD orthologs PMID:23791943.

GO Diversity

Unique GO annotations
21 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1435 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 17
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 12
Unique EC: 1
Unique GO: 21
Unique Species: 1435