The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Transcription factor DP

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Transcription factor DP

According to available literature members of this superfamily share the structure of the transcription factor DP (dimerization partner), involved in heterodimer formation with E2F, another transcription factor. This heterodimer coordinates the transcription of genes involved in cell cycle progression with both E2F and DP contributing to transcriptional activation. The contribution of DP has been proven relatively recently PMID:27825926, it occurs by virtue of the binding of its C-terminal acidic region to the plekstrin homology (PH) domain of p62 of TFIIH with even higher affinity than E2F1. As a consequence, this domain is annotated in InterPro as a transactivation domain (INTERPRO:IPR014889).

GO Diversity

Unique GO annotations
52 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
629 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 14
Unique EC:
Unique GO: 52
Unique Species: 629