The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Exocyst complex component Exo70

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Exocyst complex component Exo70

The exocyst, also known as the Sec6/8 complex in mammals, is an evolutionarily conserved eight-protein complex required for the targeting and tethering of post-Golgi vesicles to the plasma membrane. Multiple small GTPases tightly regulate its function. Structural domains comprising this superfamily share the structure of Exo70, one of the eight subunits of the exocyst which renders important for the localization of the exocyst to the plasma membrane. It interacts with TC10 and Rho3 GTPases in mammals and yeast, respectively, and also binds to the actin-polymerization complex Arp2/3 PMID:17583731,PMID:16249794,PMID:26607451.

GO Diversity

Unique GO annotations
67 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1328 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 9
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 4
Unique PDBs: 5
Structural Clusters (5A): 2
Structural Clusters (9A): 2
FunFam Clusters: 16
Unique EC:
Unique GO: 67
Unique Species: 1328