The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

PPE superfamily

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: PPE superfamily

Mycobacterium tuberculosis (Mtb) infects nearly a third of the global population and two mysterious protein families, called Pro-Glu motif-containing (PE) and Pro-Pro-Glu motif-containing (PPE) proteins, are highly expanded in Mtb and have been linked to virulence, but their function remains unknown. Proteins belonging to either of these families are exported to the bacterial surface via type VII secretion systems known as ESX. Because the PE and PPE genes are prevalent in Mtb, and absent in humans, they may serve as potential targets for the development of anti-tuberculosis intervention strategies. The function of most of these proteins remains unknown PMID:25275011,PMID:25155747,PMID:19602151.

GO Diversity

Unique GO annotations
19 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
781 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 6
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 4
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Unique EC:
Unique GO: 19
Unique Species: 781