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CATH Superfamily 1.20.1260.140

Alternative oxidase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alternative oxidase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Alternative oxidase

Members of this superfamily share the structure of the cyanide-insensitive alternative oxidase (AOX) found in all higher plants, some algae, yeasts, molds, metazoans, and pathogenic microorganisms such as Trypanosoma brucei. AOX is a diiron carboxylate protein that catalyzes the four-electron reduction of dioxygen to water by ubiquinol PMID:23487766.

This enzyme was first identified as a distinct oxidase pathway from cytochrome c oxidase as the alternative oxidase is resistant to inhibition by the poison cyanide PMID:1883834.

GO Diversity

Unique GO annotations
18 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1465 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 32
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 8
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 14
Function
Unique EC: 1
Unique GO: 18
Taxonomy
Unique Species: 1465