View in Gene3D

CATH Superfamily 1.20.1260.100

TspO/MBR protein

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
TspO/MBR protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: TspO/MBR protein

Structural domains comprising this superfamily share the structure of the translocator protein (TspO), previously known as peripheral-type benzodiazepine receptor (PBR, MBR), which is mainly found in the outer mitochondrial membrane of steroid synthesizing cells of the nervous system. In animals it forms a complex with several proteins of the mitochondrial permeability transition pore (MPTP). TspO plays a role in mitochondrial respiration, cell proliferation, immunomodulation and apoptosis PMID:24653034,PMID:25974690.

GO Diversity

Unique GO annotations
69 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
6426 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 15
Function
Unique EC:
Unique GO: 69
Taxonomy
Unique Species: 6426