The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
The mechanism of the HeLo domain-function in heterokaryon-incompatibility is still under investigation, however the HeLo domain is found in similar protein architectures as other cell death and apoptosis-inducing domains. The only other HeLo protein to which a function has been associated is LopB from Leptosphaeria maculans PMID:16336669. Although its specific role in L. maculans is unknown, LopB- mutants have impaired ability to form lesions on oilseed rape. The HeLo domain is not related to the HET domain (PFAM:PF06985) which is another domain involved in heterokaryon incompatibility.
|Domain clusters (>95% seq id):||3|
|Domain clusters (>35% seq id):||1|
|Structural Clusters (5A):||1|
|Structural Clusters (9A):||1|