The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

STAT transcription factor, all-alpha domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: STAT transcription factor, all-alpha domain

The family of signal transducers and activators of transcription (STAT) is essential in cytokine and growth factor signaling. Upon cytokine and growth factor stimulation of cells, cytoplasmic unphosphorylated STAT molecules become tyrosine phosphorylated, dimerize through reciprocal phosphotyrosine (pTyr)-SH2 interactions, accumulate in the nucleus, bind to DNA, and activate gene transcription. Subsequent inactivation involves phospho-STATs coming off DNA, becoming dephosphorylated, and exported to the cytoplasm.

Seven different STAT genes have been identified so far in mammals and the corresponding protein monomers share six structural regions: N-domain (ND), coiled-coil domain (CCD), DNA-binding domain (DBD), linker domain, SH2 domain, and transcriptional activation domain. The core fragment that characterises this proteins lack the first and last domains. Structural domains comprising this superfamily share the structure of the coiled-coil domain, designated all-alpha (INTERPRO:IPR013800). STATs form homodimeric structures which grip DNA like a pair of pliers. The C-terminal SH2 domains hold together the monomers whilst the large 4-helix-bundle domains form the handles of the pliers. The DNA is almost entirely enclosed by the protein dimer, in contact with loops from the beta-barrel and the connector domains PMID:18433722,PMID:9671298,PMID:15780933.

GO Diversity

Unique GO annotations
319 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
386 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 10
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 20
Unique EC:
Unique GO: 319
Unique Species: 386