The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

DNA helicase RuvA subunit, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ubiquitin-associated (UBA) domain

Ubiquitin-associated domain (UBA) is a small common sequence (~45 residues) found in various proteins associated with the ubiquitin/proteasome pathway, DNA excision-repair, and cell signalling (in certain protein kinases). The structure of the UBA domain consists of a compact three-helix bundle. It has been suggested that UBA domains are involved in conferring target specificity to multiple enzymes of the ubiquitination system.

The mechanism of ubiquitin binding to UBA is predicted to occur via the hydrophobic surface patch of UBA domains, which interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin.

INTERPRO:IPR015940, PFAM:PF00627,DOI:10.1016/S0022-2836(02)00302-9,DOI:10.1016/S0968-0004(96)30015-7,DOI:10.1038/4220

GO Diversity

Unique GO annotations
953 Unique GO terms

EC Diversity

Unique EC annotations
19 Unique EC terms

Species Diversity

Unique species annotations
20247 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 318
Domain clusters (>95% seq id): 101
Domain clusters (>35% seq id): 73
Unique PDBs: 166
Structural Clusters (5A): 17
Structural Clusters (9A): 7
FunFam Clusters: 371
Unique EC: 19
Unique GO: 953
Unique Species: 20247