The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:"
Structurally, S17 exhibits a DNA/RNA-binding 3-helical bundle fold, which consists of three helices with a close or partly open bundle and right-handed twist going up-and down. The three-helix bundle strikingly similar to the FF domain of human HYPA/FBP11, a novel phosphopeptide-binding fold. S17E bears a conserved positively charged surface acting as a robust scaffold for molecular recognition.
Mutations of the gene encoding ribosomal protein S17 were implicated in Diamond-Blackfan anemia (DBA). S17 is the target of the p70 S6 kinase, however the role that phosphorylation is currently unknown. Phosphorylation of human S17E has been shown to be inhibited by the immunosuppressant rapamycin. Ser and Thr residues that may serve as the site of phosphorylation.
|Domain clusters (>95% seq id):||9|
|Domain clusters (>35% seq id):||1|
|Structural Clusters (5A):||1|
|Structural Clusters (9A):||1|