The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:


Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Presenilin

The name has been chosen based on the fact that the representative domain for this superfamily matches relatively well with a Pfam domain which belongs to a superfamily known as presenilin. This is further backed by the InterPro entry for this domain. Although in InterPro a slightly different name is given, Peptidase A22A presenilin, and this name is linked to this superfamily in CATH, the Pfam designation seems more appropriate when also taking into consideration the abundance of UniProt-SwissProt entries associated with this superfamily.

GO Diversity

Unique GO annotations
221 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
742 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 8
Unique EC:
Unique GO: 221
Unique Species: 742