The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Autophagy protein 6/Beclin 1

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Autophagy protein 6/Beclin 1

Structural domains comprising this superfamily share the structure of the yeast autophagy-related protein 6 (Atg6), also designated vacuolar protein sorting-associated protein 30 (Vps30), and its human homologue Beclin 1. These proteins where initially identified to play an key role in vacuolar protein sorting. In Saccharomyces cerevisiae, ATG6 and ATG14 form a protein complex required for autophagy, known as the yeast complex I with class III phosphatidylinositol 3-kinase (PI3KC3) activity. In mammals, Beclin 1 appears to be an obligate component of two distinct PI3K complexes, one involving the human ortholog of ATG14/Barkor, which corresponds to yeast complex I, and the other involving UVRAG. The ATG14/Barkor-containing PI3K complex is believed to be responsible for autophagic vesicle nucleation whilst the UVRAG-containing complex functions in the vacuolar protein sorting pathway PMID:22310240. Beclin 1 both promotes autophagy and inhibit tumorigenesis, as it coordinately regulates the autophagy and membrane trafficking involved in several physiological and pathological processes PMID:21311563,PMID:22170155.

GO Diversity

Unique GO annotations
114 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1342 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 24
Unique EC:
Unique GO: 114
Unique Species: 1342