The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Functional Families
Superfamily: Actin cross-linking domain
ACDs are enzyme ligases that catalyse the formation of an irreversible iso-peptide bond on two actin molecules in an ATP- and Mg/Mn(2+)-dependent manner. Cross-linking depletes the cellular pool of G-actin leading to actin cytoskeleton depolymerisation PMID:19656298,PMID:22898822.
The ACD has an overall V-shape, with the active site composed of five residues in a cleft located within the two arms of the V. The first subdomain, forming the left arm of the V, is mainly composed of beta-strands, while the second subdomain, forming the right arm of the V, is helical. The first subdomain is composed of a central anti-parallel beta-sheet of 8 beta- strands, decorated by two adjacent small beta-sheets, one above the central beta-sheet and the second below. A long helix (alpha1) packs against strands beta7-beta4-beta5 from the central beta-sheet, and strand beta8 from the upper beta-sheet. Finally, the terminal helix alpha9 packs against strands beta2 and beta9. The second subdomain is composed of 7 alpha-helices (alpha2-alpha8) and does not contain any beta-strands PMID:22898822.
INTERPRO:IPR032074, PFAM:PF16671,DOI:10.1074/jbc.M112.390153
GO Diversity
EC Diversity
Species Diversity
Sequence/Structure Diversity
Superfamily Summary
| Structures | |
|---|---|
| Domains: | 8 |
| Domain clusters (>95% seq id): | 1 |
| Domain clusters (>35% seq id): | 1 |
| Unique PDBs: | 8 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 1 |
| Function | |
| Unique EC: | |
| Unique GO: | 13 |
| Taxonomy | |
| Unique Species: | 27 |