The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
2092 - - 84.7
2
1878
3D
4jtdH03 - 96.2
3
1821 - - 92.6
4
1678 - - 76.3
5
1667 - - 99.8
6
1597 - - 75.3
7
1548 - - 97.1
8
1491 - - 81.8
9
1447 - - 84.7
10
1385 - - 91.0
11
1280 - - 75.6
12
1256 - - 88.2
13
1234 - - 53.6
14
1101 - - 83.9
15
1067 - - 80.2
16
999 - - 81.9
17
996 - - 85.3
18
988 - - 82.2
19
919
3D
4kfmA02 - 95.4
20
886 - - 83.6
21
856 - - 87.8
22
795
3D
5wc5B00 - 81.3
23
781 - - 76.1
24
778 - - 72.8
25
721 - - 71.9
26
710 - - 57.1
27
678 - - 82.6
28
671 - - 91.8
29
559 - - 43.9
30
546 - - 89.0
31
544 - - 73.5
32
539 - - 76.9
33
521 - - 90.3
34
487 - - 66.3
35
Eag-related
460 - - 78.8
48
454
3D
6nmpP01 - 91.3
36
451 - - 92.3
37
442 - - 97.0
43
436
3D
6cq9B00 - 75.3
39
436
3D
5kumA02 - 77.9
38
434 - - 71.3
40
421 - - 70.2
41
418 - - 71.3
42
417 - - 75.0
44
395 - - 74.9
45
378 - - 77.3
46
375 - - 79.8
47
365 - - 80.0
49
355 - - 86.3
50
326
3D
6jb1G02 - 72.8
51
314 - - 82.3
52
306 - - 63.9
53
300 - - 51.1
54
283 - - 73.7
55
273 - - 94.1
56
266 - - 64.8
57
260 - - 80.1
58
258 - - 88.2
59
255 - - 72.0
60
232 - - 89.5
61
221 - - 95.0
62
207 - - 87.2
63
202 - - 81.7
64
198 - - 86.6
65
196 - - 88.4
66
196 - - 60.0
67
190 - - 71.9
68
184 - - 75.4
69
182 - - 58.1
70
176 - - 82.7
71
170 - - 58.6
72
161 - - 84.4
73
154 - - 92.0
74
139 - - 80.6
76
133
3D
3ukmD01 - 72.7
75
132 - - 74.8
77
124 - - 77.4
78
124 - - 87.9
79
108 - - 57.8
82
106
3D
6hu9o01 - 98.5
80
104 - - 67.4
81
103 - - 55.7
83
101 - - 27.3
84
100 - - 66.9
85
94 - - 46.4
86
89 - - 97.8
92
89
3D
3vouA00 - 27.1
87
88 - - 28.2
88
87 - - 91.2
89
84 - - 97.9
90
82 - - 77.2
91
81 - - 77.6
93
76 - - 94.0
94
75 - - 91.2
106
74
3D
4wfhB00 - 72.2
96
73 - - 59.2
97
73 - - 96.5
95
73 - - 55.3
98
71 - - 73.4
99
71 - - 40.8
100
67 - - 88.5
101
65 - - 0.0
102
65 - - 75.4
103
65 - - 59.3
104
63 - - 56.3
105
61 - - 95.8
107
59 - - 82.3
108
58 - - 77.9
109
57 - - 5.0
110
56 - - 89.0
112
55 - - 80.7
111
55 - - 44.3
113
54 - - 51.0
114
53 - - 75.4
115
53 - - 87.8
116
51 - - 57.0
118
50 - - 94.5
117
50 - - 99.5
119
49 - - 77.2
120
49 - - 67.0
122
49 - - 87.8
121
49 - - 58.8
123
49 - - 95.9
124
48 - - 76.4
125
48 - - 75.8
126
46 - - 17.8
127
45 - - 81.0
128
45 - - 82.8
276
44
3D
5iwoD00 - 74.4
129
43 - - 88.5
130
42 - - 81.3
131
41 - - 2.6
132
40 - - 88.6
133
Potassium K ChaNNel, calcium activated
40 - - 22.3
134
40 - - 92.4
135
39 - - 24.6
136
38 - - 63.4
137
38 - - 49.8
138
37 - - 73.9
139
36 - - 79.8
140
36 - - 80.9
145
35 - - 61.7
144
35 - - 83.9
142
35 - - 80.4
143
35 - - 93.6
141
35 - - 71.1
146
34 - - 16.5
150
33 - - 43.6
148
33 - - 36.3
147
33 - - 21.2
149
33 - - 74.8
152
32 - - 12.2
151
32 - - 92.3
153
31 - - 77.6
154
30 - - 68.2
155
29 - - 92.6
156
29 - - 86.0
181
28
3D
3behD02 - 52.3
158
28 - - 23.6
157
28 - - 86.7
160
27 - - 37.6
161
27 - - 32.0
159
eag-related
27 - - 12.5
162
27 - - 98.8
167
26 - - 76.1
163
26 - - 71.5
165
26 - - 67.7
166
26 - - 95.7
164
26 - - 70.6
168
24 - - 50.9
170
24 - - 86.9
169
24 - - 80.5
171
23 - - 46.7
172
23 - - 93.6
175
22 - - 59.7
174
Potassium K ChaNNel, calcium activated
22 - - 72.4
173
22 - - 58.1
178
21 - - 45.0
177
21 - - 39.0
176
21 - - 58.6
179
21 - - 63.0
180
20 - - 89.0
182
20 - - 78.3
184
20 - - 36.7
183
Potassium K ChaNNel, calcium activated
20 - - 81.3
185
20 - - 75.1
187
19 - - 73.4
186
19 - - 29.0
189
18 - - 38.4
191
18 - - 68.1
498
18
3D
2x6bA01 - 8.2
188
18 - - 35.9
190
18 - - 78.7
194
17 - - 72.6
193
17 - - 92.6
192
17 - - 43.9
197
16 - - 35.8
199
16 - - 64.8
198
16 - - 83.9
195
16 - - 73.8
196
16 - - 39.3
206
15 - - 38.8
205
15 - - 11.4
200
15 - - 70.7
207
15 - - 72.7
202
15 - - 33.6
201
15 - - 72.0
203
15 - - 22.9
204
15 - - 16.4
211
14 - - 92.7
213
14 - - 10.5
212
14 - - 6.7
215
14 - - 93.7
208
14 - - 87.1
214
14 - - 14.8
209
14 - - 70.5
216
14 - - 99.4
210
14 - - 90.2
220
13 - - 16.6
218
13 - - 26.0
221
13 - - 53.4
222
VIC
13 - - 46.2
217
13 - - 91.4
219
Potassium K ChaNNel, calcium activated
13 - - 28.2
226
12 - - 72.9
224
12 - - 9.7
227
12 - - 37.9
225
12 - - 71.9
230
Potassium
12 - - 44.4
229
12 - - 17.1
228
12 - - 22.0
223
12 - - 51.4
236
11 - - 50.1
234
11 - - 36.6
244
11 - - 92.5
237
VIC
11 - - 9.9
235
11 - - 83.9
232
AMPA
11 - - 43.6
233
11 - - 17.7
241
11 - - 58.5
240
11 - - 10.7
239
11 - - 12.3
243
11 - - 89.3
231
11 - - 7.7
238
11 - - 24.9
242
11 - - 90.0
246
10 - - 11.6
251
10 - - 36.2
250
10 - - 35.1
245
10 - - 76.9
249
10 - - 33.2
247
Potassium
10 - - 13.0
248
10 - - 75.2
260
9 - - 2.4
254
9 - - 34.5
265
9 - - 89.6
262
9 - - 6.7
256
9 - - 68.4
264
9 - - 61.2
255
9 - - 56.8
263
9 - - 63.0
257
9 - - 24.4
259
9 - - 6.9
266
9 - - 91.0
261
9 - - 2.0
749
9
3D
1lnqH01 - 0.0
253
9 - - 15.6
258
9 - - 6.4
252
9 - - 93.9
272
8 - - 13.6
275
8 - - 80.6
279
8 - - 8.1
274
8 - - 78.7
278
8 - - 76.4
267
8 - - 16.1
280
8 - - 77.1
273
8 - - 36.7
270
8 - - 90.1
269
8 - - 21.0
281
8 - - 92.5
268
8 - - 42.9
282
8 - - 93.7
277
Potassium K ChaNNel, calcium activated
8 - - 12.6
271
8 - - 13.3
285
7 - - 46.3
288
7 - - 21.0
295
7 - - 73.3
286
7 - - 94.7
296
7 - - 88.8
287
7 - - 90.6
294
7 - - 6.2
293
7 - - 8.3
292
7 - - 66.4
291
7 - - 11.8
299
7 - - 93.9
298
7 - - 82.0
284
7 - - 44.7
289
7 - - 24.6
297
7 - - 96.4
290
7 - - 14.2
283
7 - - 82.1
311
6 - - 91.8
312
6 - - 8.9
309
6 - - 75.6
300
6 - - 85.9
308
6 - - 16.6
301
6 - - 77.1
556
6
3D
3kg2D05 - 42.0
310
6 - - 90.8
303
6 - - 16.0
316
6 - - 54.9
314
6 - - 81.0
307
6 - - 9.0
302
6 - - 81.4
315
6 - - 12.0
305
6 - - 12.5
317
6 - - 72.3
313
6 - - 17.5
319
6 - - 82.3
304
6 - - 8.4
306
6 - - 5.9
318
6 - - 73.8
331
5 - - 32.0
325
5 - - 17.6
350
5 - - 85.4
337
5 - - 14.9
340
5 - - 70.3
348
5 - - 22.3
324
AMPA
5 - - 7.7
351
5 - - 76.8
342
5 - - 21.8
341
5 - - 39.8
329
5 - - 26.1
349
5 - - 47.8
346
5 - - 9.2
333
5 - - 63.3
323
BK
5 - - 7.1
352
5 - - 76.1
330
5 - - 70.2
322
5 - - 8.0
353
5 - - 74.4
354
5 - - 65.5
332
5 - - 66.9
347
5 - - 18.3
327
VIC
5 - - 10.1
320
5 - - 38.1
355
5 - - 57.3
326
5 - - 8.7
335
5 - - 4.6
334
5 - - 75.2
338
5 - - 10.9
328
5 - - 0.0
343
5 - - 43.8
321
5 - - 38.1
339
5 - - 8.0
345
5 - - 10.2
344
Potassium K ChaNNel, calcium activated
5 - - 10.2
336
5 - - 16.3
358
4 - - 80.3
378
Potassium K ChaNNel, calcium activated
4 - - 10.5
382
4 - - 24.2
389
4 - - 1.7
388
4 - - 70.2
364
4 - - 10.0
367
4 - - 41.9
391
4 - - 63.3
379
4 - - 10.2
370
4 - - 64.8
380
4 - - 8.0
381
4 - - 19.9
392
4 - - 73.4
373
4 - - 15.2
386
4 - - 45.3
366
4 - - 47.4
369
4 - - 35.2
372
4 - - 8.9
359
4 - - 24.1
360
4 - - 87.7
393
4 - - 76.8
375
4 - - 11.9
387
4 - - 57.7
368
4 - - 28.9
374
4 - - 12.1
361
4 - - 5.1
385
4 - - 47.8
377
4 - - 24.7
363
4 - - 17.8
362
4 - - 6.8
384
4 - - 62.1
376
4 - - 8.7
371
4 - - 9.7
357
4 - - 6.0
383
4 - - 74.8
365
4 - - 9.4
390
4 - - 74.3
356
4 - - 72.2
443
3 - - 33.4
437
3 - - 33.1
431
3 - - 7.8
418
Isl
3 - - 36.6
410
3 - - 81.2
430
3 - - 3.1
447
3 - - 39.8
415
3 - - 18.4
438
3 - - 31.7
444
3 - - 55.9
417
3 - - 33.8
405
3 - - 32.9
416
3 - - 15.2
399
3 - - 11.1
436
3 - - 30.5
445
3 - - 24.7
400
3 - - 61.0
441
3 - - 42.7
413
3 - - 9.7
432
3 - - 0.0
427
3 - - 7.5
446
3 - - 44.6
426
3 - - 8.6
428
3 - - 24.9
414
3 - - 11.0
394
3 - - 46.3
425
3 - - 0.0
424
3 - - 5.0
395
3 - - 2.4
434
3 - - 23.0
442
3 - - 35.4
429
3 - - 33.8
409
3 - - 47.0
412
CAKC
3 - - 5.3
433
3 - - 11.3
440
3 - - 35.8
423
3 - - 0.0
422
3 - - 0.0
402
3 - - 64.8
439
3 - - 60.8
411
3 - - 12.5
398
3 - - 66.3
407
3 - - 54.7
397
3 - - 58.0
435
3 - - 0.0
401
3 - - 10.1
404
3 - - 20.1
420
3 - - 74.8
448
3 - - 70.7
419
3 - - 0.0
406
3 - - 34.7
396
3 - - 34.2
403
3 - - 28.5
421
3 - - 0.0
408
3 - - 60.9
559
2 - - 35.6
560
2 - - 32.7
512
2 - - 42.6
463
2 - - 3.1
517
2 - - 3.4
458
2 - - 33.3
451
2 - - 2.6
454
2 - - 0.0
540
2 - - 0.0
527
2 - - 32.0
495
2 - - 1.6
548
2 - - 1.0
486
2 - - 0.7
509
2 - - 39.6
485
CAKC
2 - - 0.0
523
2 - - 10.3
460
2 - - 5.2
453
2 - - 6.8
488
2 - - 4.3
536
2 - - 11.0
452
2 - - 0.0
480
2 - - 42.9
535
2 - - 0.0
508
2 - - 38.6
541
2 - - 3.1
558
2 - - 34.8
507
2 - - 28.7
567
2 - - 48.8
506
2 - - 30.1
496
2 - - 0.0
456
2 - - 10.1
493
2 - - 1.1
525
2 - - 0.0
534
2 - - 23.5
557
2 - - 28.9
468
2 - - 30.0
475
2 - - 40.3
515
2 - - 0.9
519
2 - - 4.7
545
2 - - 0.0
542
2 - - 10.1
483
2 - - 4.0
566
2 - - 0.0
526
2 - - 32.5
500
2 - - 25.0
533
2 - - 3.9
462
2 - - 7.6
477
2 - - 41.5
514
2 - - 12.7
513
2 - - 37.5
476
2 - - 40.4
510
2 - - 36.6
449
2 - - 0.0
549
2 - - 0.0
469
2 - - 29.4
501
2 - - 12.9
490
2 - - 10.6
543
2 - - 0.0
461
2 - - 0.0
539
2 - - 10.0
565
2 - - 44.0
520
2 - - 9.9
532
2 - - 0.0
492
2 - - 8.9
511
2 - - 40.0
489
2 - - 7.7
471
2 - - 34.8
465
2 - - 41.9
502
2 - - 0.0
479
2 - - 38.3
553
2 - - 4.2
555
2 - - 31.7
538
2 - - 0.0
524
2 - - 0.0
554
2 - - 26.9
552
2 - - 0.0
521
2 - - 2.0
467
2 - - 19.4
481
2 - - 9.1
474
2 - - 37.5
564
2 - - 33.4
563
2 - - 36.4
503
2 - - 27.1
484
2 - - 2.9
544
2 - - 8.9
464
2 - - 8.8
562
2 - - 36.6
497
Potassium
2 - - 2.7
518
2 - - 0.0
472
2 - - 31.0
478
2 - - 41.0
546
2 - - 0.0
537
2 - - 7.6
522
2 - - 0.0
551
2 - - 2.3
529
2 - - 8.9
504
2 - - 26.9
459
2 - - 7.3
531
2 - - 7.8
516
2 - - 3.7
494
2 - - 4.5
487
2 - - 0.7
561
2 - - 39.7
455
2 - - 0.0
457
2 - - 37.9
550
2 - - 42.0
505
2 - - 29.9
547
2 - - 10.8
482
2 - - 4.1
499
2 - - 11.0
530
2 - - 30.6
470
2 - - 11.3
466
2 - - 17.2
450
2 - - 0.0
491
2 - - 8.1
473
2 - - 38.2
528
2 - - 10.0
737
1 - - 0.0
580
1 - - 0.0
767
1 - - 0.0
798
1 - - 0.0
805
1 - - 0.0
722
1 - - 0.0
634
1 - - 0.0
578
1 - - 0.0
695
1 - - 0.0
728
1 - - 0.0
742
1 - - 0.0
572
1 - - 0.0
675
1 - - 0.0
684
1 - - 0.0
571
1 - - 0.0
739
1 - - 0.0
662
1 - - 0.0
758
1 - - 0.0
783
1 - - 0.0
706
1 - - 0.0
789
1 - - 0.0
772
1 - - 0.0
627
1 - - 0.0
594
1 - - 0.0
715
1 - - 0.0
653
1 - - 0.0
569
1 - - 0.0
716
1 - - 0.0
686
1 - - 0.0
685
1 - - 0.0
743
1 - - 0.0
778
1 - - 0.0
720
1 - - 0.0
586
1 - - 0.0
723
1 - - 0.0
637
1 - - 0.0
595
1 - - 0.0
690
1 - - 0.0
752
1 - - 0.0
579
1 - - 0.0
683
1 - - 0.0
765
1 - - 0.0
784
1 - - 0.0
573
1 - - 0.0
762
1 - - 0.0
638
1 - - 0.0
734
1 - - 0.0
661
1 - - 0.0
800
1 - - 0.0
581
1 - - 0.0
678
1 - - 0.0
605
1 - - 0.0
607
1 - - 0.0
773
1 - - 0.0
644
1 - - 0.0
759
1 - - 0.0
694
1 - - 0.0
568
1 - - 0.0
652
1 - - 0.0
791
1 - - 0.0
796
1 - - 0.0
787
1 - - 0.0
582
1 - - 0.0
775
1 - - 0.0
746
1 - - 0.0
744
1 - - 0.0
633
1 - - 0.0
718
1 - - 0.0
700
1 - - 0.0
672
1 - - 0.0
764
1 - - 0.0
769
1 - - 0.0
803
1 - - 0.0
751
1 - - 0.0
606
1 - - 0.0
724
1 - - 0.0
691
1 - - 0.0
666
1 - - 0.0
677
1 - - 0.0
708
1 - - 0.0
650
1 - - 0.0
710
1 - - 0.0
590
1 - - 0.0
664
1 - - 0.0
588
1 - - 0.0
646
1 - - 0.0
756
1 - - 0.0
617
1 - - 0.0
651
1 - - 0.0
629
1 - - 0.0
574
1 - - 0.0
660
1 - - 0.0
806
1 - - 0.0
790
1 - - 0.0
604
1 - - 0.0
717
1 - - 0.0
671
1 - - 0.0
632
1 - - 0.0
610
1 - - 0.0
692
1 - - 0.0
663
1 - - 0.0
725
1 - - 0.0
615
1 - - 0.0
797
1 - - 0.0
766
1 - - 0.0
658
1 - - 0.0
659
KCNK5
1 - - 0.0
645
1 - - 0.0
682
1 - - 0.0
635
1 - - 0.0
575
1 - - 0.0
788
1 - - 0.0
709
1 - - 0.0
589
1 - - 0.0
614
1 - - 0.0
699
1 - - 0.0
687
1 - - 0.0
626
1 - - 0.0
583
1 - - 0.0
757
1 - - 0.0
782
1 - - 0.0
591
1 - - 0.0
745
1 - - 0.0
736
1 - - 0.0
603
1 - - 0.0
781
1 - - 0.0
620
1 - - 0.0
730
1 - - 0.0
611
1 - - 0.0
584
1 - - 0.0
665
1 - - 0.0
649
1 - - 0.0
689
1 - - 0.0
648
1 - - 0.0
642
1 - - 0.0
795
1 - - 0.0
585
1 - - 0.0
794
1 - - 0.0
727
1 - - 0.0
674
1 - - 0.0
732
1 - - 0.0
622
1 - - 0.0
776
1 - - 0.0
801
1 - - 0.0
754
1 - - 0.0
747
1 - - 0.0
704
1 - - 0.0
681
1 - - 0.0
619
1 - - 0.0
698
1 - - 0.0
621
1 - - 0.0
680
1 - - 0.0
679
1 - - 0.0
598
1 - - 0.0
780
1 - - 0.0
647
1 - - 0.0
786
1 - - 0.0
740
1 - - 0.0
602
1 - - 0.0
719
1 - - 0.0
612
1 - - 0.0
701
1 - - 0.0
731
1 - - 0.0
668
1 - - 0.0
688
1 - - 0.0
750
1 - - 0.0
657
1 - - 0.0
774
1 - - 0.0
768
1 - - 0.0
693
1 - - 0.0
673
1 - - 0.0
593
1 - - 0.0
770
1 - - 0.0
641
1 - - 0.0
576
1 - - 0.0
761
1 - - 0.0
616
1 - - 0.0
640
1 - - 0.0
738
1 - - 0.0
804
1 - - 0.0
623
1 - - 0.0
755
1 - - 0.0
777
1 - - 0.0
628
1 - - 0.0
733
1 - - 0.0
630
1 - - 0.0
748
1 - - 0.0
608
1 - - 0.0
711
1 - - 0.0
705
1 - - 0.0
785
1 - - 0.0
599
eag-related
1 - - 0.0
609
1 - - 0.0
587
1 - - 0.0
667
1 - - 0.0
741
1 - - 0.0
714
1 - - 0.0
601
1 - - 0.0
779
1 - - 0.0
753
1 - - 0.0
697
1 - - 0.0
726
1 - - 0.0
707
1 - - 0.0
624
1 - - 0.0
792
1 - - 0.0
656
1 - - 0.0
729
1 - - 0.0
771
1 - - 0.0
760
1 - - 0.0
596
1 - - 0.0
735
1 - - 0.0
613
1 - - 0.0
721
1 - - 0.0
669
1 - - 0.0
702
1 - - 0.0
639
1 - - 0.0
636
1 - - 0.0
577
1 - - 0.0
643
1 - - 0.0
600
1 - - 0.0
696
1 - - 0.0
713
1 - - 0.0
676
1 - - 0.0
670
1 - - 0.0
625
1 - - 0.0
592
1 - - 0.0
631
1 - - 0.0
712
1 - - 0.0
763
1 - - 0.0
793
1 - - 0.0
570
1 - - 0.0
654
1 - - 0.0
618
1 - - 0.0
655
1 - - 0.0
703
1 - - 0.0
799
1 - - 0.0
597
1 - - 0.0
802
1 - - 0.0