The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: GTP cyclohydrolase I, N-terminal domain

GTP cyclohydrolase I catalyses the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP. This reaction is the first step in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects. The enzyme is a homodecameric complex (a dimer of pentamers) containing one zinc ion per subunit. The pentamerisation leads to the formation of a 20-stranded antiparallel beta-barrel.

This superfamily entry consists of the N-terminal domain found in GTP cyclohydrolases I, which has been well conserved throughout evolution across bacterial and eukaryotic species. The GTP-CH-I monomer folds into an alpha+beta structure with a predominantly helical N-terminal part.

PFAM:PF01227, INTERPRO:IPR020602,PMID:12559918,PMID:7663943

GO Diversity

Unique GO annotations
64 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
11371 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 161
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 3
Unique PDBs: 16
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 13
Unique EC: 2
Unique GO: 64
Unique Species: 11371