The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SATB1 is comprised by ULD and CUTL domains at the N terminus, a homeodomain (HD) at the C terminus, and a CUT1-CUT2 tandem in the center. High affinity DNA-binding is achieved through tetramer formation, which occurs through the N-terminal ULD. Structural domains comprising this superfamily share the structure of the CULT domain of SATB proteins, essential for the contact between DNA and SATB1. This CULT (CUT repeat-like domain), was named after the remarkable structure similarity it shares with the CUT1 domain. Overall, the tetrameric SATB1 binds one or two DNA fragments via coordination of the CUTL domain, the CUT1-CUT2 tandem, and HD domains to act as a global chromatin organizer and gene expression regulator PMID:25124042.
Structures | |
---|---|
Domains: | 4 |
Domain clusters (>95% seq id): | 3 |
Domain clusters (>35% seq id): | 1 |
Unique PDBs: | 3 |
Alignments | |
Structural Clusters (5A): | 1 |
Structural Clusters (9A): | 1 |
FunFam Clusters: | 2 |
Function | |
Unique EC: | |
Unique GO: | 45 |
Taxonomy | |
Unique Species: | 175 |