This name has been altered since the latest official CATH+ release (v4_2_0). At the point of the last release, this superfamily was waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: HRDC domain

Structural domains comprising this superfamily share the structure of the helicase and RNaseD C-terminal (HRDC) domain, involved in interactions with both DNA and protein, is conserved among members of the RecQ helicase family, including the human Werner and Bloom syndrome proteins, and regulates helicase activity by virtue of variations in its surface residues PMID:10647186. RecQ helicases unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, structure which resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.

The HRDC domain is also found in eukaryotic and archaeal RNA polymerase II subunit RBP4 PMID:15591044,PMID:11741548.

GO Diversity

Unique GO annotations
254 Unique GO terms

EC Diversity

Unique EC annotations
19 Unique EC terms

Species Diversity

Unique species annotations
10986 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 40
Domain clusters (>95% seq id): 18
Domain clusters (>35% seq id): 14
Unique PDBs: 29
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 17
Unique EC: 19
Unique GO: 254
Unique Species: 10986