The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
5' to 3' exonuclease, C-terminal subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
4839
37706
EC
3D
1c7yA02 - 71.8
26991
27495
3D
1wcnA01 - 95.7
27158
24973
3D
1u9lA00 - 92.8
27356
21039
EC
3D
1cooA00 - 95.9
27387
17964
EC
3D
1exnA01 - 94.5
27104
9817
EC
3D
4ir1A03 - 100.0
26552
9186
EC
3D
2owoA06 - 88.6
25329
8335
EC
3D
1d8yA04 - 98.4
26549
7280
EC
- - 99.3
27260
6895
EC
3D
1kftA00 - 93.8
27145
5867
EC
3D
3c1yA03 - 99.5
14177
5489
EC
- - 88.3
26553
5360
EC
3D
2owoA07 - 94.4
27289
5015
EC
- - 99.0
26494
4486
EC
3D
2h5xA02 - 100.0
26025
3810
EC
- - 97.4
26469
3405
EC
- - 92.1
26952
3065
EC
- - 100.0
26327
RuvA
2691
EC
- - 97.4
27233
2537
EC
3D
1b22A00 - 76.8
27404
2443
EC
- - 98.3
27135
2276
EC
- - 89.1
26250
2272
EC
- - 97.2
26304
2073
EC
3D
2maxA00 - 94.0
26564
2021
EC
- - 97.1
27263
1972
EC
- - 99.4
26542
1942
EC
3D
1ixrA02 - 99.5
27434
1887
EC
3D
2q0zX02 - 97.5
25211
1730
EC
- - 89.8
27307
1697
EC
- - 99.7
6288
1525
EC
- - 58.6
26375
1365
EC
- - 99.1
25990
1176
EC
- - 90.5
26439
1135
EC
- - 100.0
27221
1134
EC
3D
3gqcA03 - 98.8
26993
1121
EC
- - 87.0
24975
1039
EC
- - 43.2
25027
1023
EC
- - 87.8
26851
910
EC
- - 94.3
27148
903
EC
- - 99.2
26233
902
EC
- - 90.5
26535
Polydeoxyribonucleotide synthase (NAD+
874
EC
- - 95.5
27286
824
EC
- - 96.2
27139
769 - - 99.5
26203
755
EC
- - 91.3
26986
743
EC
- - 98.0
26679
695
EC
- - 65.6
27081
695
EC
- - 98.6
27117
601
EC
3D
1aroP05 - 75.3
5475
596
EC
- - 66.5
27024
545
EC
3D
1bpxA02 - 93.6
27241
531
EC
3D
1z00A01 - 95.6
27275
524
EC
- - 89.5
27008
508
EC
- - 97.1
27322
477
EC
- - 95.6
26412
464
EC
- - 98.5
26588
424
EC
- - 99.6
26493
415
EC
- - 99.2
6009
415
EC
- - 1.7
27227
381
EC
3D
2nrtA02 - 100.0
27017
374
EC
- - 82.4
26995
371 - - 92.1
1091
363
EC
- - 23.6
4110
345
EC
- - 0.0
26026
328
EC
3D
1rztA02 - 85.3
27077
276
EC
3D
3mr2A03 - 92.3
27163
269
EC
3D
2zj5A04 - 97.7
26289
265
EC
- - 94.5
26569
264
EC
- - 93.7
27253
256
EC
- - 94.9
5088
254
EC
- - 4.8
26484
241
EC
- - 97.0
24995
227
EC
- - 21.7
9492
214
EC
3D
1tfrA02 - 4.8
12044
210
EC
- - 6.8
27082
207
3D
2lyhA00 - 88.2
26309
205
EC
- - 90.8
27341
NAD+
203
EC
- - 45.2
27231
202
EC
- - 92.0
26453
196
EC
3D
1jmsA02 - 88.7
26488
190
EC
- - 94.8
27032
184
EC
- - 89.5
25008
NAD+
172
EC
- - 15.6
27271
172
3D
1rxvA02 - 97.7
2058
161
EC
- - 3.9
25143
159
3D
3qe9Y02 - 53.4
26938
154
EC
- - 96.9
24981
134
EC
3D
1t3nA03 - 63.7
27138
116
EC
- - 99.6
25606
107
EC
3D
4lzdA02 - 65.8
26343
99
EC
- - 89.0
24753
99
EC
- - 53.5
27362
97
3D
2kz3A00 - 76.6
26175
97
EC
- - 80.6
25961
97 - - 70.7
27154
88
EC
- - 76.1
25569
87
EC
- - 47.0
4724
78
EC
- - 17.1
24852
78
3D
1z00B00 - 74.6
27175
72
3D
1a76A02 - 85.1
25370
71
EC
3D
4bxoA02 - 55.2
26373
69
EC
- - 88.7
25084
69
EC
- - 35.1
26948
66
EC
- - 73.9
13102
65 - - 0.0
15358
62
EC
- - 9.5
3649
60
EC
3D
1jihA03 - 1.6
13061
59 - - 0.0
26011
58
EC
- - 96.5
4117
57
3D
2aq4A04 - 1.4
26120
57
EC
- - 79.7
25283
56
EC
- - 58.1
27003
56
EC
3D
1dgsA06 - 98.5
25445
55 - - 30.4
24878
53
EC
- - 42.4
27447
52
EC
- - 95.8
27071
52
EC
- - 67.8
26348
NAD+
52
EC
- - 78.6
27247
51
EC
- - 94.4
26674
50
EC
- - 84.9
25427
45
EC
- - 19.7
25490
44 - - 38.1
6947
42
EC
- - 14.6
25882
37
EC
- - 66.8
18472
37
EC
- - 15.8
16591
36
EC
- - 0.0
16980
36
EC
- - 0.0
2230
36
EC
- - 65.6
6013
36
EC
- - 1.6
27391
35 - - 75.3
26754
NAD+
35
EC
- - 83.6
27038
35 - - 85.3
26190
34
EC
- - 58.2
25164
34
EC
- - 54.8
4691
34
EC
- - 46.6
26998
33 - - 92.0
27088
32
EC
3D
1t4gA01 - 87.2
2910
30
EC
- - 8.8
24856
28
3D
2bkeA01 - 32.1
26650
26
EC
- - 40.1
11675
25 - - 0.0
26350
25
3D
1pznA01 - 86.3
26090
25
EC
- - 56.7
8275
24
EC
- - 23.1
8136
23
EC
- - 1.6
27228
21 - - 31.5
25829
21 - - 19.2
27189
20 - - 97.3
25659
19
EC
- - 35.1
4528
18
EC
- - 7.0
16488
18
EC
- - 14.8
25570
18
EC
- - 49.4
22023
18
EC
- - 34.7
27346
17
EC
- - 46.5
27083
17
EC
- - 91.9
25147
17
EC
- - 46.8
9490
16
EC
- - 10.7
26106
16
EC
- - 52.8
26051
15 - - 58.2
25373
15
EC
- - 24.2
6858
15
EC
- - 14.8
4888
14 - - 25.5
27164
14 - - 89.2
21082
14
EC
- - 23.2
24968
13
EC
- - 29.1
23239
12
EC
- - 18.6
25694
11
EC
- - 38.0
24762
11
EC
- - 18.1
2600
11
EC
- - 3.0
25066
10
EC
- - 34.5
25467
9 - - 25.9
8191
9
EC
- - 1.7
12335
9
EC
- - 19.2
25471
9
EC
- - 38.6
8814
9
EC
- - 19.9
25892
8
EC
- - 10.1
16987
8
EC
- - 5.9
2696
7
EC
- - 6.1
9590
Polydeoxyribonucleotide synthase [NAD(+
7
EC
- - 2.8
2694
7
EC
- - 5.8
2112
7
EC
- - 1.9
2603
7
EC
- - 2.9
8250
6
EC
- - 6.2
25794
6
EC
- - 36.9
12635
6 - - 15.8
8484
6
EC
- - 12.4
1690
6
EC
- - 3.2
6845
6
EC
- - 1.7
26971
6
3D
3q8kA02 - 45.2
10491
5 - - 7.5
25881
5 - - 28.6
26735
5
EC
- - 46.4
25823
5
EC
- - 12.6
27063
5
EC
- - 79.5
8269
5
EC
- - 5.9
26201
4
EC
- - 0.0
4733
4 - - 0.0
17509
4 - - 0.0
124
4
EC
- - 16.0
314
4
EC
- - 0.0
4378
4
EC
- - 5.1
6929
4
EC
- - 0.0
24997
4
EC
- - 5.6
15964
4 - - 0.0
26914
4
EC
- - 53.8
27385
4 - - 54.5
27373
4
EC
- - 48.4
19101
4 - - 5.3
9554
4
EC
- - 0.0
25530
4 - - 0.0
1784
4
EC
- - 6.2
9587
4
EC
- - 0.0
26755
4
EC
- - 0.0
2332
4
EC
- - 0.0
25764
3
EC
- - 32.9
2242
3
EC
- - 0.0
13068
3
EC
- - 0.0
25387
3 - - 19.0
19705
3 - - 14.0
22580
3 - - 9.1
2063
3
EC
- - 11.8
6765
2
EC
- - 0.0
22940
2 - - 10.0
26741
2
EC
- - 46.7
25719
2
EC
- - 35.1
52
2
EC
- - 6.0
3911
2
EC
- - 0.0
2187
POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]
2
EC
- - 9.5
26897
2
EC
- - 45.8
1968
2
EC
- - 0.0
2152
2
EC
- - 3.0
27377
2
EC
- - 47.8
2136
2
EC
- - 3.3
4726
2
EC
- - 1.5
25640
2
EC
- - 0.0
6050
2
EC
- - 14.1
10951
2
EC
- - 10.7
22758
2
EC
- - 0.0
25539
2
EC
- - 25.4
25005
2
EC
- - 20.1
7889
2
EC
- - 0.0
3637
2 - - 10.1
88
2
EC
- - 6.0
9559
2 - - 10.1
3692
2
EC
- - 9.2
25777
2
EC
- - 39.6
25679
2
EC
- - 0.0
26702
2 - - 39.3
20241
1
EC
- - 0.0
20949
1
EC
- - 0.0
10967
1 - - 0.0
25054
1
EC
- - 0.0
22436
1 - - 0.0
15980
1 - - 0.0
6015
1
EC
- - 0.0
6011
1
EC
- - 0.0
9586
1 - - 0.0
2648
1 - - 0.0
25548
1
EC
- - 0.0
26671
1
EC
- - 0.0
9528
1
EC
- - 0.0
2111
1
EC
- - 0.0
25710
1
EC
- - 0.0
26736
1
EC
- - 0.0
27282
1
EC
- - 0.0
1907
1
EC
- - 0.0
5109
1
EC
- - 0.0
18476
1 - - 0.0