The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Large-conductance mechanosensitive channel, MscL; domain 1

According to the literature, members of the structural domains which comprise this superfamily correspond to the structure of domain 1 of MscL, acronym which stands for large-conductance mechanosensitive channel. This domain is annotated in both Pfam (PFAM:PF01741) and InterPro (INTERPRO:IPR001185). However, both databases annotate this as a single chain domain whilst CATH subdivides it in two distinct domains. Thus, the term domain 1 has been included in the name of the superfamily for specificity.

MscL forms a homopentameric channel and, as we can see from the structure of this superfamilies's representative domain, each subunit is comprised of two transmembrane alpha helices PMID:19701184. This channel opens in response to stretch forces in the membrane lipid bilayer and it is believed to be involved in osmoregulation.

GO Diversity

Unique GO annotations
17 Unique GO terms

EC Diversity

Unique EC annotations
8 Unique EC terms

Species Diversity

Unique species annotations
8938 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 11
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 3
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 8
Unique GO: 17
Unique Species: 8938