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CATH Superfamily 1.10.10.2150

Ribosomal RNA-processing protein 8, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribosomal RNA-processing protein 8, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal RNA-processing protein 8, N-terminal domain

This superfamily represents the N-terminal domain of the ribosomal RNA-processing protein 8 (RRP8). Rrp8 is a nucleolar methyltransferase with a Rossman-like fold. In yeast, it is involved in pre-rRNA cleavage at site A2 and is responsible for a base methylation of the 25S rRNA. In humans it is also known as nucleomethylin (NML), and it is important for mediating the assembly of the energy-dependent nucleolar silencing complex (eNoSC), which regulates rRNA transcription in response to glucose deprivation. NML represses rDNA transcription by promoting H3K9 methylation and establishing heterochromatin across the rDNA.

PFAM:PF05148, INTERPRO:IPR042036,PMID:10864042,PMID:23180764,PMID:23897426,PMID:18485871

GO Diversity

Unique GO annotations
23 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1406 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC: 1
Unique GO: 23
Taxonomy
Unique Species: 1406