The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Bacterial DNA polymerase III alpha subunit, thumb domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Bacterial DNA polymerase III alpha subunit, thumb domain

Superfamily is a group of 4 compact alpha helices between two small beta strands.

In literature associated with bacterial DNA polymerase III alpha subunit, residues 433-510 (the same residues of the CATH superfamily) are referred to as the thumb domain.

The thumb domain is involved in processivity of the polymerase - holding the template strand in place so that binding doesn't need to occur with each dNTP added to the strand.

GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
11305 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 10
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 7
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Unique EC: 1
Unique GO: 10
Unique Species: 11305