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CATH Superfamily 1.10.10.1500

JmjC domain-containing ribosomal oxygenase (ROX), dimer domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
JmjC domain-containing ribosomal oxygenase (ROX), dimer domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: JmjC domain-containing ribosomal oxygenase (ROX), dimer domain

According to scientific literature, the JmjC domain-containing proteins belong to a large family of oxygenases possessing distinct substrate specificities which are involved in the regulation of different biological processes, such as gene transcription, RNA processing and translation.

Key roles: histone lysine demethylase and ribosomal histidine hydroxylase activity

Representative proteins: MYC-induced nuclear antigen (Mina53), bifunctional lysine-specific demethylase and histidyl-hydroxylase Nucleolar protein 66 (NO66) - catalyse histidine hydroxylation in humans

GO Diversity

Unique GO annotations
24 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
417 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 32
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 13
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Function
Unique EC: 1
Unique GO: 24
Taxonomy
Unique Species: 417