The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Spidroin domain, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Spidroin domain, C-terminal domain

Spider silk fibres are made from spidroin proteins, notably aciniform spidroin 1 (AcSp1), minor ampullate spidroin (MiSp), major ampullate spidroin (MaSp) and tubuliform spidroin 1 (TuSp1). Dragline silk is composed of two proteins, major ampullate spidroin 1 (MaSp1) and major ampullate spidroin 2 (MaSp2) PMID:16283740. MaSp1 contains five alpha-helices PMID:17096540.

Spidroins contain repetitive units capped between non-repetitive N-terminal (NTD) and C-terminal (CTD) domains, whose composition varies among species and thus determines the variety of mechanical properties of spider silks. The CTDs are conserved among spider silk proteins. This superfamily comprises spidroin-like CTDs largely present in invertebrates, particularly arachnids.

PFAM:PF11260,INTERPRO:IPR021001,DOI:10.1371/journal.pone.0056142,DOI:10.1021/bm401709v,DOI:.org/10.1038/nature08936,DOI:10.1073/pnas.0813255106,DOI:10.1371/journal.pbio.1001921

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
56 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 9
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 2
Unique PDBs: 5
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 56