The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Mediator of RNA polymerase II, submodule Med31 (Soh1)

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Mediator of RNA polymerase II, submodule Med31 (Soh1)

This superfamily includes mediator, a multiprotein complex that regulates transcription by interacting with RNA polymerase II and transcription activators and repressors. The entry represents Med31 subunit (known as Soh1 in Saccharomyces cerevisiae) and its homologues.

The middle module of the mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31, organised as a four helix bundle. In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport PMID:19057509.

Soh1 is responsible for the repression of temperature sensitive growth of the Hpr1 mutant PMID:7982575 and has been found to be a component of the RNA polymerase II transcription complex. Soh1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the Soh1 protein may serve to couple these two processes PMID:8849885.


GO Diversity

Unique GO annotations
27 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1366 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 5
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 10
Unique EC:
Unique GO: 27
Unique Species: 1366