The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

RNA polymerase sigma-54 factor, core-binding domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: RNA polymerase sigma-54 factor, core-binding domain

This superfamily represents the sigma-54 domain that binds core RNA polymerase and triggers the initiation of transcription. The structure of sigma-54 comprises 2 subdomains: the N-terminal is a four-helical subdomain with negative charge that most likely binds to the core polymerase, while the C-terminal is a three-helix bundle with positive patch that binds to the DNA PMID:19426742. This domain makes a direct interaction with the core RNA polymerase to form an enhancer dependent holoenzyme PMID:10894718. The centre of this domain contains a very weak similarity to a helix-turn-helix motif, which may represent a DNA binding domain.


GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
7239 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Unique EC:
Unique GO: 10
Unique Species: 7239