The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: MAN1, winged-helix domain

This superfamily entry represents the winged-helix domain located at the C-terminal end of MAN1, an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation. The C-terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad PMID:16648637. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands PMID:15611647. The carboxyl-terminal nucleoplasmic region of MAN1, comprising residues 655-910, exhibits two potential globular domains, an alpha/beta structure which corresponds to a winged-helix domain. The first region of the domain is conserved in all MAN1 analogs. The N-terminal half of the domain is mainly alpha-helical, whereas the C-terminal half is composed of two large beta-strands arranged in a twisted anti-parallel beta-sheet PMID:16648637.


GO Diversity

Unique GO annotations
40 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
888 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 2
Unique GO: 40
Unique Species: 888