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CATH Superfamily 1.10.10.1140

Glutamine-dependent NAD+ synthetase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutamine-dependent NAD+ synthetase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Glutamine-dependent NAD+ synthetase, C-terminal domain

This superfamily entry represents a domain found at the C-terminus of glutamine-dependent NAD+ synthetase.

NAD+ biosynthesis is absolutely dependent on the activity of a multifunctional glutamine-dependent NAD+ synthetase, which catalyzes the ATP-dependent formation of NAD+ at the synthetase domain using ammonia derived from L-glutamine in the glutaminase domain PMID:22280445.

PFAM:PF02540,INTERPRO:IPR022310,DOI:10.1042/BJ20112210,DOI:10.1038/nsmb.1567

GO Diversity

Unique GO annotations
5 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
2400 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 21
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC: 1
Unique GO: 5
Taxonomy
Unique Species: 2400