CATH Classification

Domain Context

CATH Clusters

Superfamily Aconitase, domain 4
Functional Family Aconitate hydratase, mitochondrial

Enzyme Information

4.2.1.3
Aconitate hydratase.
based on mapping to UniProt P16276
Citrate = isocitrate.
-!- Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. -!- The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. -!- Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate. -!- Formerly EC 4.2.1.4.

UniProtKB Entries (1)

P16276
ACON_PIG
Sus scrofa
Aconitate hydratase, mitochondrial

PDB Structure

PDB 7ACN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of aconitase with isocitrate and nitroisocitrate bound.
Lauble, H., Kennedy, M.C., Beinert, H., Stout, C.D.
Biochemistry