CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Functional Family Proteasome subunit beta type-3

Enzyme Information

UniProtKB Entries (2)

A4HN55
A4HN55_LEIBR
Leishmania braziliensis
Proteasome subunit beta
A4HSQ5
A4HSQ5_LEIIN
Leishmania infantum
Proteasome subunit beta

PDB Structure

PDB 6QM7
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C.W., Pena, I., Bingham, R.P., Bueren-Calabuig, J.A., Cantizani, J., Cebrian, D., Craggs, P.D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E.J., Korczynska, J., MacLean, L., Manthri, S., Martinez, M.S., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F.R.C., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R.J., Zuccotto, F., Horn, D., Ferguson, M.A.J., Fairlamb, A.H., Fiandor, J.M., Martin, J., Gray, D.W., Miles, T.J., Gilbert, I.H., Read, K.D., Marco, M., Wyatt, P.G.
Proc.Natl.Acad.Sci.USA