CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.70.20
Functional Family

Enzyme Information

4.3.99.4
Choline trimethylamine-lyase.
based on mapping to UniProt Q30W70
Choline = trimethylamine + acetaldehyde.
-!- The enzyme utilizes a glycine radical to break the C-N bond in choline. -!- Found in choline-degrading anaerobic bacteria.

UniProtKB Entries (1)

Q30W70
CUTC_DESAG
Desulfovibrio alaskensis G20
Choline trimethylamine-lyase

PDB Structure

PDB 6ND3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.
Orman, M., Bodea, S., Funk, M.A., Campo, A.M., Bollenbach, M., Drennan, C.L., Balskus, E.P.
J.Am.Chem.Soc.
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