CATH Domain 6m9kA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.320	Lambda Exonuclease; Chain A
	3.90.320.10

Domain Context

CATH Clusters

Superfamily	3.90.320.10
Functional Family

Enzyme Information

3.1.11.3

Exodeoxyribonuclease (lambda-induced).

based on mapping to UniProt P03697

Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.

-!- Preference for double-stranded DNA. -!- Does not attack single-strand breaks. -!- Similar enzymes: T4, T5 and T7 exonucleases, mammalian DNase IV. -!- Formerly EC 3.1.4.28.

UniProtKB Entries (1)

P03697

EXO_LAMBD

Escherichia virus Lambda

Exonuclease

PDB Structure

PDB	6M9K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the Red beta C-terminal domain in complex with lambda Exonuclease reveals an unexpected homology with lambda Orf and an interaction with Escherichia coli single stranded DNA binding protein. Caldwell, B.J., Zakharova, E., Filsinger, G.T., Wannier, T.M., Hempfling, J.P., Chun-Der, L., Pei, D., Church, G.M., Bell, C.E. Nucleic Acids Res.