CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family

Enzyme Information

3.4.21.100
Sedolisin.
based on mapping to UniProt P42790
Hydrolysis of the B chain of insulin at 13-Glu-|-Ala-14, 15-Leu-|-Tyr-16 and 25-Phe-|-Tyr-26 and angiotensin I at 4-Tyr-|-Ile-5. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-|-Phe(NO(2))-Arg-Leu.
-!- An enzyme secreted by Pseudomonas sp. No. 101. -!- Optimum pH 4. -!- It is distinguished from EC 3.4.21.101 by its insensitivity to EPNP and from EC 3.4.23.31 by this property and by its unrelated amino- acid sequence. -!- Inhibited by tyrostatin, a peptide aldehyde. -!- Belongs to peptidase family S53. -!- Formerly EC 3.4.23.37.

UniProtKB Entries (1)

P42790
PICP_PSESR
Pseudomonas sp. 101
Pseudomonalisin

PDB Structure

PDB 6M9D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Wlodawer, A., Li, M., Gustchina, A., Dauter, Z., Uchida, K., Oyama, H., Goldfarb, N.E., Dunn, B.M., Oda, K.
Biochemistry