CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Putative ketol-acid reductoisomerase 2

Enzyme Information

1.1.1.86
Ketol-acid reductoisomerase (NADP(+)).
based on mapping to UniProt Q97YJ9
(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.
-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.

UniProtKB Entries (1)

Q97YJ9
ILVC2_SACS2
Saccharolobus solfataricus P2
Putative ketol-acid reductoisomerase 2

PDB Structure

PDB 6JCW
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
Chen, C.Y., Chang, Y.C., Lin, B.L., Lin, K.F., Huang, C.H., Hsieh, D.L., Ko, T.P., Tsai, M.D.
J. Am. Chem. Soc.