CATH Domain 6i0pA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.10800	NadA-like

Domain Context

CATH Clusters

Superfamily	NadA-like
Functional Family	Quinolinate synthase A

Enzyme Information

2.5.1.72

Quinolinate synthase.

based on mapping to UniProt Q9X1X7

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate.

-!- Quinolinate synthase catalyzes the second step in the de novo biosynthesis of NAD(+) from aspartate in some bacteria, with EC 1.4.3.16 catalyzing the first step and EC 2.4.2.19 the third step. -!- In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme.

UniProtKB Entries (1)

Q9X1X7

NADA_THEMA

Thermotoga maritima MSB8

Quinolinate synthase A

PDB Structure

PDB	6I0P
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination. Saez Cabodevilla, J., Volbeda, A., Hamelin, O., Latour, J.M., Gigarel, O., Clemancey, M., Darnault, C., Reichmann, D., Amara, P., Fontecilla-Camps, J.C., Ollagnier de Choudens, S. Chem.Commun.(Camb.)