CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Acetylcholinesterase

Enzyme Information

3.1.1.8
Cholinesterase.
based on mapping to UniProt P06276
An acylcholine + H(2)O = choline + a carboxylate.
-!- Acts on a variety of choline esters and a few other compounds.

UniProtKB Entries (1)

P06276
CHLE_HUMAN
Homo sapiens
Cholinesterase

PDB Structure

PDB 6I0C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Chalupova, K., Korabecny, J., Bartolini, M., Monti, B., Lamba, D., Caliandro, R., Pesaresi, A., Brazzolotto, X., Gastellier, A.J., Nachon, F., Pejchal, J., Jarosova, M., Hepnarova, V., Jun, D., Hrabinova, M., Dolezal, R., Zdarova Karasova, J., Mzik, M., Kristofikova, Z., Misik, J., Muckova, L., Jost, P., Soukup, O., Benkova, M., Setnicka, V., Habartova, L., Chvojkova, M., Kleteckova, L., Vales, K., Mezeiova, E., Uliassi, E., Valis, M., Nepovimova, E., Bolognesi, M.L., Kuca, K.
Eur.J.Med.Chem.