CATH Domain 6hv0A03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1440	de novo design (two linked rop proteins)
	1.20.1440.180	KEN domain

Domain Context

CATH Clusters

Superfamily	KEN domain
Functional Family	Serine/threonine-protein kinase/endoribonuclease IRE1

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt O75460 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
3.1.26.-	Endoribonucleases producing 5'-phosphomonoesters. based on mapping to UniProt O75460

UniProtKB Entries (1)

ERN1_HUMAN

Homo sapiens

Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB	6HV0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease. Colombano, G., Caldwell, J.J., Matthews, T.P., Bhatia, C., Joshi, A., McHardy, T., Mok, N.Y., Newbatt, Y., Pickard, L., Strover, J., Hedayat, S., Walton, M.I., Myers, S.M., Jones, A.M., Saville, H., McAndrew, C., Burke, R., Eccles, S.A., Davies, F.E., Bayliss, R., Collins, I. J.Med.Chem.