CATH Classification

Domain Context

CATH Clusters

Superfamily MoeA, C-terminal, domain IV
Functional Family Molybdopterin molybdenumtransferase

Enzyme Information

2.7.7.75
Molybdopterin adenylyltransferase.
based on mapping to UniProt Q03555
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
-!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). -!- The reaction requires a divalent cation such as Mg(2+) or Mn(2+). -!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes EC 2.10.1.1. -!- Formerly EC 2.7.7.n5.
2.10.1.1
Molybdopterin molybdotransferase.
based on mapping to UniProt Q03555
Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.
-!- Catalyzes the insertion of molybdenum into the ene-dithiol group of molybdopterin. -!- In eukaryotes this reaction is catalyzed by the N-terminal domain of a fusion protein whose C-terminal domain catalyzes EC 2.7.7.75.

UniProtKB Entries (1)

P20236
GBRA3_RAT
Rattus norvegicus
Gamma-aminobutyric acid receptor subunit alpha-3

PDB Structure

PDB 6HSN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod, V.B., Hausrat, T.J., Schaefer, N., Kuhn, M., Christensen, N.R., Tessmer, I., Maric, H.M., Madsen, K.L., Sotriffer, C., Villmann, C., Kneussel, M., Schindelin, H.
Neuron