CATH Domain 6h67B07

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.150	RNA polymerase II, Rpb2 subunit, wall domain

Domain Context

CATH Clusters

Superfamily	2.40.50.150
Functional Family	DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt P22138

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P40422

RPAB4_YEAST

Saccharomyces cerevisiae S288C

DNA-directed RNA polymerases I, II, and III subunit RPABC4

PDB Structure

PDB	6H67
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Structural basis of RNA polymerase I stalling at UV light-induced DNA damage. Sanz-Murillo, M., Xu, J., Belogurov, G.A., Calvo, O., Gil-Carton, D., Moreno-Morcillo, M., Wang, D., Fernandez-Tornero, C. Proc. Natl. Acad. Sci. U.S.A.