CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Carboxylic ester hydrolase

Enzyme Information

3.1.1.13
Sterol esterase.
based on mapping to UniProt P19835
A steryl ester + H(2)O = a sterol + a fatty acid.
-!- A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. -!- Activated by bile salts.
3.1.1.3
Triacylglycerol lipase.
based on mapping to UniProt P19835
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
-!- The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.

UniProtKB Entries (1)

P19835
CEL_HUMAN
Homo sapiens
Bile salt-activated lipase

PDB Structure

PDB 6H18
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates.
Touvrey, C., Courageux, C., Guillon, V., Terreux, R., Nachon, F., Brazzolotto, X.
Toxicology