CATH Classification

Domain Context

CATH Clusters

Superfamily MoaB/Mog-like domain
Functional Family Molybdopterin molybdenumtransferase

Enzyme Information

2.7.7.75
Molybdopterin adenylyltransferase.
based on mapping to UniProt Q39054
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
-!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). -!- The reaction requires a divalent cation such as Mg(2+) or Mn(2+). -!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes EC 2.10.1.1. -!- Formerly EC 2.7.7.n5.
2.10.1.1
Molybdopterin molybdotransferase.
based on mapping to UniProt Q39054
Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.
-!- Catalyzes the insertion of molybdenum into the ene-dithiol group of molybdopterin. -!- In eukaryotes this reaction is catalyzed by the N-terminal domain of a fusion protein whose C-terminal domain catalyzes EC 2.7.7.75.

UniProtKB Entries (1)

Q39054
CNX1_ARATH
Arabidopsis thaliana
Molybdopterin biosynthesis protein CNX1

PDB Structure

PDB 6GB0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The functional principle of eukaryotic molybdenum insertases.
Krausze, J., Hercher, T.W., Zwerschke, D., Kirk, M.L., Blankenfeldt, W., Mendel, R.R., Kruse, T.
Biochem. J.