CATH Domain 6ftcA04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.390	Enolase-like; domain 1
	3.30.390.30	FAD/NAD-linked reductase, C-terminal dimerisation domain

Domain Context

CATH Clusters

Superfamily	3.30.390.30
Functional Family	Thioredoxin reductase 1, cytoplasmic

Enzyme Information

UniProtKB Entries (1)

G4V8J4_SCHMA

Schistosoma mansoni

Thioredoxin glutathione reductase

PDB Structure

PDB	6FTC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. Silvestri, I., Lyu, H., Fata, F., Boumis, G., Miele, A.E., Ardini, M., Ippoliti, R., Bellelli, A., Jadhav, A., Lea, W.A., Simeonov, A., Cheng, Q., Arner, E.S.J., Thatcher, G.R.J., Petukhov, P.A., Williams, D.L., Angelucci, F. ACS Chem. Biol.