CATH Classification

Domain Context

CATH Clusters

Superfamily NadA-like
Functional Family Quinolinate synthase A

Enzyme Information

2.5.1.72
Quinolinate synthase.
based on mapping to UniProt Q9X1X7
Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate.
-!- Quinolinate synthase catalyzes the second step in the de novo biosynthesis of NAD(+) from aspartate in some bacteria, with EC 1.4.3.16 catalyzing the first step and EC 2.4.2.19 the third step. -!- In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme.

UniProtKB Entries (1)

Q9X1X7
NADA_THEMA
Thermotoga maritima MSB8
Quinolinate synthase A

PDB Structure

PDB 6F4L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA.
Volbeda, A., Saez Cabodevilla, J., Darnault, C., Gigarel, O., Han, T.H., Renoux, O., Hamelin, O., Ollagnier-de-Choudens, S., Amara, P., Fontecilla-Camps, J.C.
ACS Chem. Biol.