CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.11710 | Cyclodipeptide synthase |
Domain Context
CATH Clusters
| Superfamily | Cyclodipeptide synthase |
| Functional Family | Cyclo(L-leucyl-L-leucyl) synthase |
Enzyme Information
| 2.3.2.22 |
Cyclo(L-leucyl-L-leucyl) synthase.
based on mapping to UniProt Q4L2X9
2 L-leucyl-tRNA(Leu) = 2 tRNA(Leu) + cyclo(L-leucyl-L-leucyl).
-!- The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue. -!- The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L- methionyl).
|
UniProtKB Entries (1)
| Q4L2X9 |
CDLS_STAHJ
Staphylococcus haemolyticus JCSC1435
Cyclo(L-leucyl-L-leucyl) synthase
|
PDB Structure
| PDB | 6EZ3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for partition of the cyclodipeptide synthases into two subfamilies.
J. Struct. Biol.
|