CATH Domain 6evrA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.200	Carbonic Anhydrase II
	3.10.200.10	Alpha carbonic anhydrase

Domain Context

CATH Clusters

Superfamily	Alpha carbonic anhydrase
Functional Family	Carbonic anhydrase 2

Enzyme Information

4.2.1.1

Carbonic anhydrase.

based on mapping to UniProt P00915

H(2)CO(3) = CO(2) + H(2)O.

-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00915

CAH1_HUMAN

Homo sapiens

Carbonic anhydrase 1

PDB Structure

PDB	6EVR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. Chiaramonte, N., Bua, S., Ferraroni, M., Nocentini, A., Bonardi, A., Bartolucci, G., Durante, M., Lucarini, L., Chiapponi, D., Dei, S., Manetti, D., Teodori, E., Gratteri, P., Masini, E., Supuran, C.T., Romanelli, M.N. Eur J Med Chem