CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Glucose-6-phosphate 1-dehydrogenase

Enzyme Information

1.1.1.49
Glucose-6-phosphate dehydrogenase (NADP(+)).
based on mapping to UniProt P11413
D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH.
-!- The enzyme catalyzes a step of the pentose phosphate pathway. -!- The enzyme is specific for NADP(+), cf. EC 1.1.1.363 and EC 1.1.1.388.

UniProtKB Entries (1)

P11413
G6PD_HUMAN
Homo sapiens
Glucose-6-phosphate 1-dehydrogenase

PDB Structure

PDB 6E07
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.
Hwang, S., Mruk, K., Rahighi, S., Raub, A.G., Chen, C.H., Dorn, L.E., Horikoshi, N., Wakatsuki, S., Chen, J.K., Mochly-Rosen, D.
Nat Commun