CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-directed RNA polymerase, insert domain
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P9WGZ1
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P9WGY7
RPOC_MYCTU
Mycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit beta'

PDB Structure

PDB 6DVB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of ECF-sigma-factor-dependent transcription initiation.
Lin, W., Mandal, S., Degen, D., Cho, M.S., Feng, Y., Das, K., Ebright, R.H.
Nat Commun