CATH Domain 6d59B01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.870	Son of sevenless (SoS) protein; Chain S, domain 1
	1.20.870.10	Son of sevenless (SoS) protein Chain: S domain 1

Domain Context

CATH Clusters

Superfamily	Son of sevenless (SoS) protein Chain: S domain 1
Functional Family	son of sevenless homolog 1 isoform X1

Enzyme Information

UniProtKB Entries (1)

SOS1_HUMAN

Homo sapiens

Son of sevenless homolog 1

PDB Structure

PDB	6D59
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W. J. Med. Chem.